920113-02-6|P276-00,P276-00 is an analog of flavopiridol where the piperidine moiety has been changed for a pyrrolidine and resulted from an intense structure-activity and co-crystallization effort [24,46,47]. P276-00 inhibits efficiently CDK9 (IC50: 20 nM), but also other CDKs such as CDK1 (IC50: 79 nM), CDK2 (IC50: 224 nM) and CDK4 (IC50: 63 nM). The development is being performed by Nicholas Piramal Company and phase II clinical trials for various types of tumours have been announced (e.g., recurrent and/or locally advanced head and neck cancer, relapsed and/or refractory mantle cell lymphoma). Although several phase II trials ended in 2012/2013 no results could be found.
Copyright © 2014-2018 上海腾渤医药科技有限公司. TubePharm All Rights Reserved. 沪ICP备15036794
电话：+86 021 5433 8626 传真：+86 021 5433 8626*801 E-mail: firstname.lastname@example.org